Charlotte Cunningham-Rundles | Immunology | Best Research Article Award

Dr. Charlotte Cunningham-Rundles | Immunology | Best Research Article Award

Mount Sinai School of Medicine | United States

Charlotte Cunningham-Rundles is the David S. Gottesman Professor in the Department of Medicine and Professor in the Department of Pediatrics at Mount Sinai Medical Center. She holds an M.D. from Columbia University and a Ph.D. in Immunology from New York University, building her career on the study of the pathogenesis, characterization, and treatment of human immune deficiency diseases. Trained as an internist with a long-standing pediatric appointment, she has devoted her professional life to bridging clinical practice and research in immunology. At Mount Sinai, she established the Primary Immune Deficiency Clinic, a major referral center for infants, children, and adults with suspected or confirmed immune deficiency disorders, attracting patients nationally and internationally. She is a co-founder of USIDNET, an NIH-supported research consortium affiliated with the Immune Deficiency Foundation, and serves as a member and treasurer of the IUIS Expert Committee on Primary Immune Deficiency. Her laboratory focuses on defects of human B cells, the most common genetic defects in immune disorders. She has extensively studied common variable immune deficiency (CVID), producing influential work on its demographics, immunologic parameters, and medical complications. Her recent investigations have advanced understanding of autoimmune and inflammatory conditions in CVID, revealing key insights into interferon signaling and innate immune dysregulation.

Profile: Scopus 

Featured Publications 

"Common Variable Immunodeficiency Clinical Manifestations Are Shaped by Presence and Type of Heterozygous NFKB1 Variants"

"Disease diagnostics using machine learning of B cell and T cell receptor sequences"

"Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses"

"Primary versus Secondary Immune Thrombocytopenia (ITP): A Meeting Report from the 2023 McMaster ITP Summit"

"Common variable immunodeficiency: autoimmune cytopenias and advances in molecular diagnosis"

Prof. Zhiguo Wang – Polypharmacology – Outstanding Scientist Award

Prof. Zhiguo Wang - Polypharmacology - Outstanding Scientist Award

Guangdong Provincial Key Laboratory for Mechanistic and Translational Research on Bidirectional Complications among Chronic Conditions, Jinan University, China - China 

Author Profile

SCOPUS 

ORCID

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Early academic pursuits 🎓

Zhiguo Wang embarked on his academic journey with a strong foundation in pharmacology, pursuing his studies at Harbin Medical University in Heilongjiang, China. His early work laid the groundwork for a distinguished career focused on understanding chronic diseases and their complex interrelations. His rigorous training and commitment to research established him as a formidable scholar in the field of cardiovascular and chronic disease research.

Professional endeavors 🏢

Throughout his career, Zhiguo has held numerous prestigious positions, demonstrating his leadership in the medical and research communities. He is currently the Director and Professor at the Guangdong Provincial Key Laboratory for Mechanistic and Translational Research on Chronic Disease Complex Complications at Jinan University in Guangzhou, China. His role as a chief scientist and professor across various departments at the First Affiliated Hospital of Jinan University reflects his multifaceted expertise. Additionally, he has contributed significantly as a Distinguished Professor at Harbin Medical University and held a visiting professorship at the Montreal Heart Institute in Canada.

Contributions and research focus 🔬

Zhiguo's research focuses on the mechanistic and translational aspects of chronic diseases, particularly the bidirectional complications arising from these conditions. He has pioneered studies that explore the pathophysiology of cardiovascular diseases and their links to metabolic disorders. His work employs innovative Polypharmacology methodologies to investigate the underlying mechanisms of disease progression and to develop effective therapeutic strategies, aiming to improve patient outcomes in chronic disease management.

Accolades and recognition 🏅

Zhiguo Wang has received numerous accolades for his contributions to medical research, including being a Fellow of the American Heart Association (FAHA) and a Polypharmacology Fellow of the European Society of Cardiology (FESC). His recognition as a Marion L. Munro Research Scholar by the Canadian Diabetes Association further underscores his impactful research in chronic disease mechanisms. His extensive publication record in high-impact journals reflects his influence and standing in the academic community.

Impact and influence 🌍

Zhiguo's research has made a significant impact on the understanding of chronic diseases and their complications, influencing both clinical practice and public health strategies. His work is instrumental in bridging the gap between basic science and clinical applications, ultimately contributing to improved therapeutic approaches Polypharmacology for patients suffering from chronic conditions. He is a sought-after speaker and mentor, inspiring the next generation of researchers in his field.

Legacy and future contributions 🔮

As a leader in chronic disease research, Zhiguo Wang’s legacy is built on his commitment to advancing scientific knowledge and improving patient care. His ongoing research aims to unravel the complexities of chronic disease interactions and to foster innovative therapeutic strategies. With a focus on translational research, Zhiguo's future contributions are poised to drive significant advancements in understanding and treating chronic conditions, leaving a lasting impact on the field and enhancing healthcare outcomes globally.

Notable Publications