Charlotte Cunningham-Rundles | Immunology | Best Research Article Award

Dr. Charlotte Cunningham-Rundles | Immunology | Best Research Article Award

Mount Sinai School of Medicine | United States

Charlotte Cunningham-Rundles is the David S. Gottesman Professor in the Department of Medicine and Professor in the Department of Pediatrics at Mount Sinai Medical Center. She holds an M.D. from Columbia University and a Ph.D. in Immunology from New York University, building her career on the study of the pathogenesis, characterization, and treatment of human immune deficiency diseases. Trained as an internist with a long-standing pediatric appointment, she has devoted her professional life to bridging clinical practice and research in immunology. At Mount Sinai, she established the Primary Immune Deficiency Clinic, a major referral center for infants, children, and adults with suspected or confirmed immune deficiency disorders, attracting patients nationally and internationally. She is a co-founder of USIDNET, an NIH-supported research consortium affiliated with the Immune Deficiency Foundation, and serves as a member and treasurer of the IUIS Expert Committee on Primary Immune Deficiency. Her laboratory focuses on defects of human B cells, the most common genetic defects in immune disorders. She has extensively studied common variable immune deficiency (CVID), producing influential work on its demographics, immunologic parameters, and medical complications. Her recent investigations have advanced understanding of autoimmune and inflammatory conditions in CVID, revealing key insights into interferon signaling and innate immune dysregulation.

Profile: Scopus 

Featured Publications 

"Common Variable Immunodeficiency Clinical Manifestations Are Shaped by Presence and Type of Heterozygous NFKB1 Variants"

"Disease diagnostics using machine learning of B cell and T cell receptor sequences"

"Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses"

"Primary versus Secondary Immune Thrombocytopenia (ITP): A Meeting Report from the 2023 McMaster ITP Summit"

"Common variable immunodeficiency: autoimmune cytopenias and advances in molecular diagnosis"

Prof. Mingqian fang – Immunology & Hematology – Women Researcher Award

Prof. Mingqian fang - Immunology & Hematology - Women Researcher Award

Kunming Institute of Zoology, Chinese Academy of Sciences - Zimbabwe

Author Profile

ORCID 

Early academic pursuits 🎓

Mingqian fang embarked on his academic journey with a keen interest in biology and medical sciences, eventually specializing in the study of disease pathogenesis. his early work centered on understanding how infections and inflammatory responses influence mental health, particularly focusing on stress-induced depression. his educational background laid a strong foundation for his future research in both neuroscience and cardiovascular diseases. as a professor at the kunming institute of zoology, chinese academy of sciences, he has consistently contributed to groundbreaking research.

Professional endeavors 🏢

As a professor at the kunming institute of zoology, mingqian has dedicated his career to exploring the connections between stress, depression, and physiological responses to infections. his research has not only deepened our understanding of how stress exacerbates mental health disorders, but has also opened pathways to developing effective treatments for both depression and cardiovascular diseases. his expertise extends to studying natural toxin peptides, with particular focus on their biomedical applications.

Contributions and research focus 🔬

Mingqian’s primary research areas include the pathogenesis of diseases like depression under stressful stimuli, such as infections and inflammation, and the Immunology & Hematology development of innovative drugs to treat these conditions. his notable work includes the discovery of how lipopolysaccharide-binding protein expression is increased by stress, promoting depressive symptoms by inhibiting monoamine synthesis. he has also explored the role of bat-derived peptides and how they impact neuroinflammation, contributing significantly to the understanding of the body's immune response to various stressors.

Accolades and recognition 🏅

Mingqian fang’s research has been widely recognized in the scientific community, with publications in high-impact journals such as immunity and pnas. his works have earned accolades due to their novel insights into how biological systems respond to stress and disease. his research in immune responses and toxin peptides has Immunology & Hematology been acknowledged globally, with his papers being published in top-tier journals with high impact factors, demonstrating the importance and quality of his findings.

Impact and influence 🌍

Mingqian’s research has had a far-reaching impact on both neuroscience and cardiovascular medicine. by linking mental health issues like depression to biological processes such as inflammation, he has paved the way for new treatment methodologies. his work on natural toxins also holds promise for creating innovative drugs Immunology & Hematology that could target specific disease mechanisms, further influencing the pharmaceutical industry and biomedical research. his influence spans across multiple fields, combining neuroscience, immunology, and pharmacology.

Legacy and future contributions 🔮

Mingqian fang’s ongoing work ensures that his legacy in the scientific world continues to grow. his pioneering research on stress-related depression and cardiovascular conditions is laying the groundwork for future innovations in drug development. by bridging the gap between neuroscience and immunology, his research will likely inspire further interdisciplinary studies aimed at improving human health. his work on bat-derived peptides, in particular, opens exciting possibilities for novel therapies.

Notable Publications 

  • Title: The Price of P2X7R Freedom is Neuroinflammation
    Authors: Fang M, Lai R
    Journal: Immunity
    Date: March 2024
    DOI: 10.1016/j.immuni.2024.02.009
  • Title: Transferrin Is Up-Regulated by Microbes and Acts as a Negative Regulator of Immunity to Induce Intestinal Immunotolerance
    Authors: Tang X, Fang M, Cheng R, Niu J, Huang X, Xu K, Wang G, Sun Y, Liao Z, Zhang Z et al.
    Journal: Research (Washington, D.C.)
    Date: January 2024
    DOI: 10.34133/research.0301
  • Title: Lipopolysaccharide-Binding Protein Expression is Increased by Stress and Inhibits Monoamine Synthesis to Promote Depressive Symptoms
    Authors: Fang M, Li Y, Liao Z, Wang G, Cao Q, Li Y, Duan Y, Han Y, Deng X, Wu F et al.
    Journal: Immunity
    Date: February 2023
    DOI: 10.1016/j.immuni.2023.02.002
  • Title: An Undefined Cystatin CsCPI1 from Tea Plant Camellia sinensis Harbors Antithrombotic Activity
    Authors: Fang M, Cha JH, Wang HC, Ye P, Chen B, Chen M, Yang WH, Yan X
    Journal: Biomedicine & Pharmacotherapy
    Date: January 2023
    DOI: 10.1016/j.biopha.2023.114285
  • Title: Hypoxia and Low Temperature Upregulate Transferrin to Induce Hypercoagulability at High Altitude
    Authors: Li M, Tang X, Liao Z, Shen C, Cheng R, Fang M, Wang G, Li Y, Tang S, Xie L et al.
    Journal: Blood
    Date: November 2022
    DOI: 10.1182/blood.2022016410