Mount Sinai School of Medicine | United States
Charlotte Cunningham-Rundles is the David S. Gottesman Professor in the Department of Medicine and Professor in the Department of Pediatrics at Mount Sinai Medical Center. She holds an M.D. from Columbia University and a Ph.D. in Immunology from New York University, building her career on the study of the pathogenesis, characterization, and treatment of human immune deficiency diseases. Trained as an internist with a long-standing pediatric appointment, she has devoted her professional life to bridging clinical practice and research in immunology. At Mount Sinai, she established the Primary Immune Deficiency Clinic, a major referral center for infants, children, and adults with suspected or confirmed immune deficiency disorders, attracting patients nationally and internationally. She is a co-founder of USIDNET, an NIH-supported research consortium affiliated with the Immune Deficiency Foundation, and serves as a member and treasurer of the IUIS Expert Committee on Primary Immune Deficiency. Her laboratory focuses on defects of human B cells, the most common genetic defects in immune disorders. She has extensively studied common variable immune deficiency (CVID), producing influential work on its demographics, immunologic parameters, and medical complications. Her recent investigations have advanced understanding of autoimmune and inflammatory conditions in CVID, revealing key insights into interferon signaling and innate immune dysregulation.
Profile: Scopus
Featured Publications
"Common Variable Immunodeficiency Clinical Manifestations Are Shaped by Presence and Type of Heterozygous NFKB1 Variants"
"Disease diagnostics using machine learning of B cell and T cell receptor sequences"
"Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses"
"Primary versus Secondary Immune Thrombocytopenia (ITP): A Meeting Report from the 2023 McMaster ITP Summit"
"Common variable immunodeficiency: autoimmune cytopenias and advances in molecular diagnosis"