Shiraz University| Iran

Mohammad Sadegh Taghizadeh is based at the Agricultural Faculty of Shiraz University (Institute of Biotechnology, Shiraz-Isfahan Highway, Shiraz, Iran) where he pursues advanced research in bioactive small molecules and peptides—whether synthesised by ribosomes or derived from proteins. His work spans in vitro isolation, purification and structural-physicochemical characterisation of these compounds, their pharmacological and sensory properties, and complementary in silico design and target-interaction studies. He also explores recombinant production of bioactive peptides using plant and bacterial expression systems. Prior to his current role, he earned a bachelor’s in agricultural engineering (plant protection) at Shahid Bahonar University of Kerman, a master’s in plant biotechnology at University of Guilan (thesis: factors affecting virulence genes of Agrobacterium tumefaciens in Arabidopsis thaliana mutants), and a PhD in biotechnology at Shiraz University (dissertation: functional properties of bio-active peptides derived from plant resources). He gained research experience at the Medical University of Vienna (on discovery of a novel cyclotide targeting the CCK2 receptor) and later led a project on plant-derived bioinsecticides funded by the National Elite Foundation of Iran, while also teaching as a TA in plant genetic engineering, molecular markers and plant tissue culture at Shiraz University. His research has steadily contributed to the field of peptide biotechnology, with growing recognition: his h-index currently stands at (unknown) and his publication and citation counts are steadily rising as he continues to establish himself in the realm of bioactive small molecules and recombinant peptide production.

Featured Publications

Abbasi, A., Taghizadeh, M. S., Moghadam, A., Niazi, A., Lotfi, M., & Taghavi, S.-M. (2025). A comprehensive insight into ultrasound-assisted protein extraction from Camelina sativa and de-bittering of resulting hydrolysates with emphasis on their structural, physicochemical, sensory, and biological properties. Food Chemistry, 445, 145435.

Taghizadeh, M. S., Niazi, A., Mirzapour-Kouhdasht, A., Pereira, E. C., & Garcia-Vaquero, M. (2025). Enhancing cyclotide bioproduction: Harnessing biological synthesis methods and various expression systems for large-scale manufacturing. Critical Reviews in Biotechnology, 45(1), 1–20.

Hoseini, S., Moghadam, A., Palizban, A., Hoseini, F., Taghizadeh, M. S., Choopani, A., & Hoseini, F. (2025). Immune boosting by pharmaceutical C-phycocyanin, in vitro and in silico effects on peripheral blood mononuclear cells. Health Biotechnology and Biopharma, 8(1), 1–10.

Lotfi, M., Keshvari, T., Taghizadeh, M. S., Afsharifar, A., Moghadam, A., Aram, F., & Niazi, A. (2025). Optimizing Camelina sativa oil extraction and its cytotoxicity using RSM by emphasis on antioxidant properties, physical characteristics, and molecular docking insights. Industrial Crops and Products, 215, 120334.

Taghizadeh, M. S., Mirzapour-Kouhdasht, A., & Huang, J.-Y. (2025, December). Unraveling the structure-activity relationship and molecular mechanisms for targeted therapeutic applications of food-derived angiotensin-I-converting enzyme inhibitory peptides. Food Bioscience, 65, 107820.

Mr. Kyle Frey - Pharmaceutical Manufacturing - Best Researcher Award

Quotient Sciences - United States

Author Profile

ORCID

🎓 Early academic pursuits

Kyle Frey graduated summa cum laude from the university of delaware, where his academic brilliance earned him early acceptance into thomas jefferson medical university. this strong foundation in pharmaceutical sciences laid the groundwork for a career defined by precision, innovation, and scientific curiosity. his early academic journey was marked by deep analytical thinking and a desire to explore cross-disciplinary fields such as acoustical engineering, materials science, and even power electronics in drug formulation.

💼 Professional endeavors

Kyle’s professional journey began with a pivotal role at dupont, where he was instrumental in creating the first knowledge database for thin film development in oral drug delivery systems. at quotient sciences, he introduced advanced predictive stability testing models and transformed the organization’s formulation capabilities. kyle spent over five years independently exploring resonant acoustic mixing technology, ultimately becoming one of the leading figures in this niche field. his expertise in power electronics helped bridge concepts between acoustic forces and pharmaceutical behavior, guiding groundbreaking discoveries in mixing efficiency and dosage homogeneity.

🔬 Contributions and research focus

Kyle Frey’s research revolves around resonant acoustic mixing (ram) technologies, a field that combines theoretical acoustics, engineering, and pharmaceutical science. after three months of rigorous experimentation and more than 20 months of conceptual development, he unveiled the first substantial body of work on the subject at aaps pharmsci 360 in 2023. his first two research papers—published in pharmaceutical research (nov. 2023) and the international journal of pharmaceutics (apr. 2025)—laid the conceptual groundwork for his current primary Pharmaceutical Manufacturing manuscript. his studies challenge conventional mixing paradigms and incorporate principles from power electronics to redefine how acoustic energy interacts with pharmaceutical particles.

🌟 Impact and influence

Kyle’s work has not only pushed the envelope in pharmaceutical mixing technologies but has also opened up a multidisciplinary approach to formulation science. his blend of curiosity, perseverance, and innovation has led to widespread recognition within the pharmaceutical community. his pioneering use of acoustics, informed by principles in power electronics, has Pharmaceutical Manufacturing inspired many professionals to reconsider how energy input and material properties can be harmonized for novel drug delivery systems. by developing a comprehensive framework for understanding ram, he has created a new pathway for scientists worldwide to follow.

📚 Academic cites

To date, kyle frey has three highly cited original publications: two in prestigious peer-reviewed journals (nov. 2023 and apr. 2025) and one presented at aaps pharmsci 360 in 2023. his publications have gained attention for their originality and depth, reflecting the five years of independent work he dedicated to the field. several other manuscripts—one completed and Pharmaceutical Manufacturing another in progress—promise to further expand the academic community’s understanding of resonant acoustic phenomena. his upcoming third manuscript is anticipated to synthesize all prior work and become a definitive resource in the domain.

🔭 Legacy and future contributions

Kyle's journey began with a simple thought—"i wonder if sound can be used to monitor crystallization processes"—and evolved into a life-long mission. his passion for this subject has shaped his identity as a scientist and continues to guide his work. with five total manuscripts (including two pending review articles), kyle aims to leave a lasting legacy in pharmaceutical acoustics and formulation science. his commitment to integrating advanced scientific theories, including power electronics, into real-world applications ensures that his contributions will influence future generations of researchers.

Notable Publications

Title: Sample preparation techniques to enhance uniformity of Low-Dose blends mixed by resonant acoustic mixing technology
Author: Kyle Frey
Journal: International Journal of Pharmaceutics
Title: Use of Resonant Acoustic Mixing Technology for Ultra-Low-Dose Blending in a Single-Step Mixing Process
Authors: Kyle Frey, Helen Baker, Dale K. Purcell, Andrew L. Lewis, David A. Engers
Journal: Pharmaceutical Research
Title: Use of Resonant Acoustic Technology for Ultra-Low Dose Blending in a Single-Step Mixing Process
Author: Kyle Frey
Journal: AAPS PharmSci 360 (Conference Poster)

Mohammad Sadegh Taghizadeh | Drug Discovery | Best Researcher Award

Dr. Mohammad Sadegh Taghizadeh | Drug Discovery | Best Researcher Award

Shiraz University| Iran

Featured Publications