Quotient Sciences - United States
Author Profile
ORCID
🎓 Early academic pursuits
Kyle Frey graduated summa cum laude from the university of delaware, where his academic brilliance earned him early acceptance into thomas jefferson medical university. this strong foundation in pharmaceutical sciences laid the groundwork for a career defined by precision, innovation, and scientific curiosity. his early academic journey was marked by deep analytical thinking and a desire to explore cross-disciplinary fields such as acoustical engineering, materials science, and even power electronics in drug formulation.
💼 Professional endeavors
Kyle’s professional journey began with a pivotal role at dupont, where he was instrumental in creating the first knowledge database for thin film development in oral drug delivery systems. at quotient sciences, he introduced advanced predictive stability testing models and transformed the organization’s formulation capabilities. kyle spent over five years independently exploring resonant acoustic mixing technology, ultimately becoming one of the leading figures in this niche field. his expertise in power electronics helped bridge concepts between acoustic forces and pharmaceutical behavior, guiding groundbreaking discoveries in mixing efficiency and dosage homogeneity.
🔬 Contributions and research focus
Kyle Frey’s research revolves around resonant acoustic mixing (ram) technologies, a field that combines theoretical acoustics, engineering, and pharmaceutical science. after three months of rigorous experimentation and more than 20 months of conceptual development, he unveiled the first substantial body of work on the subject at aaps pharmsci 360 in 2023. his first two research papers—published in pharmaceutical research (nov. 2023) and the international journal of pharmaceutics (apr. 2025)—laid the conceptual groundwork for his current primary Pharmaceutical Manufacturing manuscript. his studies challenge conventional mixing paradigms and incorporate principles from power electronics to redefine how acoustic energy interacts with pharmaceutical particles.
🌟 Impact and influence
Kyle’s work has not only pushed the envelope in pharmaceutical mixing technologies but has also opened up a multidisciplinary approach to formulation science. his blend of curiosity, perseverance, and innovation has led to widespread recognition within the pharmaceutical community. his pioneering use of acoustics, informed by principles in power electronics, has Pharmaceutical Manufacturing inspired many professionals to reconsider how energy input and material properties can be harmonized for novel drug delivery systems. by developing a comprehensive framework for understanding ram, he has created a new pathway for scientists worldwide to follow.
📚 Academic cites
To date, kyle frey has three highly cited original publications: two in prestigious peer-reviewed journals (nov. 2023 and apr. 2025) and one presented at aaps pharmsci 360 in 2023. his publications have gained attention for their originality and depth, reflecting the five years of independent work he dedicated to the field. several other manuscripts—one completed and Pharmaceutical Manufacturing another in progress—promise to further expand the academic community’s understanding of resonant acoustic phenomena. his upcoming third manuscript is anticipated to synthesize all prior work and become a definitive resource in the domain.
🔭 Legacy and future contributions
Kyle's journey began with a simple thought—"i wonder if sound can be used to monitor crystallization processes"—and evolved into a life-long mission. his passion for this subject has shaped his identity as a scientist and continues to guide his work. with five total manuscripts (including two pending review articles), kyle aims to leave a lasting legacy in pharmaceutical acoustics and formulation science. his commitment to integrating advanced scientific theories, including power electronics, into real-world applications ensures that his contributions will influence future generations of researchers.
Notable Publications
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Title: Sample preparation techniques to enhance uniformity of Low-Dose blends mixed by resonant acoustic mixing technology
Author: Kyle Frey
Journal: International Journal of Pharmaceutics
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Title: Use of Resonant Acoustic Mixing Technology for Ultra-Low-Dose Blending in a Single-Step Mixing Process
Authors: Kyle Frey, Helen Baker, Dale K. Purcell, Andrew L. Lewis, David A. Engers
Journal: Pharmaceutical Research
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Title: Use of Resonant Acoustic Technology for Ultra-Low Dose Blending in a Single-Step Mixing Process
Author: Kyle Frey
Journal: AAPS PharmSci 360 (Conference Poster)