Alina Esterhuizen | Neurogenetics | Research Excellence Award

Dr. Alina Esterhuizen | Neurogenetics | Research Excellence Award

UCT/NHLS | South Africa

Dr. Alina Esterhuizen is a professionally registered medical scientist specializing in Molecular Human Genetics, Neurogenetics with a strong dual focus on translational research and molecular diagnostic service leadership. Her expertise lies in integrating advanced genomic research into routine clinical diagnostics, ensuring that scientific discoveries directly improve patient care. She has extensive experience in clinical genetic testing, quality management systems, validation and implementation of new diagnostic protocols, and the continuous enhancement of laboratory standards within accredited healthcare environments. Her research centers on the genetics of neurodevelopmental and neurodegenerative disorders, with particular emphasis on paediatric epilepsies and neuromuscular diseases. She has contributed significantly to understanding the genetic architecture of complex epilepsy in African paediatric populations, advancing the identification of pathogenic variants and improving diagnostic yield in underrepresented groups. Her work also includes mutation profiling in Duchenne muscular dystrophy, supporting the development and application of emerging gene-based therapeutic approaches. Beyond research and diagnostics, she is actively engaged in teaching, mentorship, and supervision of students and laboratory professionals. She is deeply committed to strengthening local genomic capacity and promoting equitable access to genetic testing services across Africa, ensuring that precision medicine becomes accessible to diverse and historically underserved populations.

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Featured Publications


Current practice in diagnostic genetic testing of the epilepsies

– Epileptic Disorders 24 (5), 765–786 (2022) | Citations: 100

Clinical application of epilepsy genetics in Africa: is now the time?

– Frontiers in Neurology 9, 276 (2018) | Citations: 39

C9orf72 repeat expansions in South Africans with amyotrophic lateral sclerosis

– Journal of the Neurological Sciences 401, 51–54 | Citations: —

Dr. Mohadeseh Khoshandam – genetics – Best Researcher Award

Department of Reproductive Biology, Academic Center for Education, Culture and Research, Qom Branch, Qom - Iran

AUTHOR PROFILE 

ORCID

🌟 EARLY ACADEMIC PURSUITS

Mohadeseh Khoshandam embarked on her academic journey with a strong passion for molecular genetics. She earned her Bachelor's degree in Molecular Genetics from the Science and Arts University of Yazd in 2014, laying the foundation for her future endeavors. Her quest for advanced knowledge led her to pursue a Master’s degree in Cell and Molecular Biology at the National Institute of Genetic Engineering and Biotechnology (NIGEB) in Tehran, where she graduated in 2018. She further solidified her expertise by enrolling in a Ph.D. program in Molecular Genetics at NIGEB, where she successfully defended her dissertation in 2021.

🧬 PROFESSIONAL ENDEAVORS

As a dedicated educator and researcher, Mohadeseh has taken up multiple roles that highlight her expertise. She currently serves as a coach at the National Institute of Genetic Engineering and Biotechnology, contributing to scientific training and mentorship. Her teaching roles at Qom University and her involvement in workshops on bioinformatics and stem cell research reflect her commitment to education. She has also played an instrumental role in guiding participants in the Stem Cells and Regenerative Medicine Olympiad.

🔬 CONTRIBUTIONS AND RESEARCH FOCUS

Mohadeseh’s research portfolio reflects her innovative approach to addressing critical challenges in genetics and molecular biology. She has worked on developing gene-editing techniques genetics using CRISPR-Cas9 to combat diseases such as β-thalassemia, sickle cell anemia, and hemophilia A. Her research on pathological angiogenesis in breast cancer models and the use of peptide nanocarriers has opened new avenues in cancer therapy. She has also explored the role of nanotechnology in enhancing human sperm quality and improving semen parameters in clinical trials, showcasing her interdisciplinary research focus.

🏆 ACCOLADES AND RECOGNITION

Mohadeseh’s work has earned her recognition within the academic and research community. Her innovative projects, particularly in gene editing and regenerative medicine, have contributed genetics significantly to the advancement of molecular genetics. Her role as a coach and mentor highlights her influence in nurturing the next generation of scientists.

🌍 IMPACT AND INFLUENCE

Through her groundbreaking research and educational contributions, Mohadeseh has significantly impacted the fields of molecular genetics and regenerative medicine. Her work on CRISPR-Cas9 and nanotechnology applications in reproductive biology has paved the way for novel therapeutic interventions. Her teachings and workshops have inspired numerous students and genetics professionals, reinforcing her role as a transformative figure in her domain.

🔗 LEGACY AND FUTURE CONTRIBUTIONS

With her expertise in molecular genetics and dedication to education, Mohadeseh Khoshandam is poised to leave a lasting legacy in her field. Her pioneering work in gene editing and genetics nanotechnology holds promise for further advancements in genetic therapy and regenerative medicine. As she continues her journey, her commitment to innovation and mentorship ensures a bright future for the scientific community she serves.

NOTABLE PUBLICATIONS 

  1. Title: CRISPR, CAR-T, and NK: Current applications and future perspectives
    Authors: Mohadeseh Khoshandam, Hossein Soltaninejad, Amir Ali Hamidieh, Saman Hosseinkhani
    Journal: Genes & Diseases
  2. Title: Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine
    Authors: Mohadeseh Khoshandam, Hossein Soltaninejad, Marziyeh Mousazadeh, Amir Ali Hamidieh, Saman Hosseinkhani
    Journal: Genes & Diseases
  3. Title: Recent advances in developing 3D culture systems of spermatogonial stem cell preservation and differentiation: A narrative review
    Authors: Leyla Fath-Bayati, Leila Naserpour, Mohadeseh Khoshandam, Rahil Jannatifar, Hoda Fazaeli
    Journal: International Journal of Reproductive BioMedicine (IJRM)
  4. Title: The role of MicroRNAs in female and male human reproduction: A Narrative Review
    Authors: Mohadeseh Khoshandam, Leila Naserpour, Hossein Soltaninejad, Hadi Zare-Zardini, Ashraf Alsadat Hoseiny, Neda Golpar Raboki, Elahe Sadat Mousavi
    Journal: Preprint
  5. Title: CRISPR and Artificial intelligence to improve precision medicine: Future Perspectives and Potential Limitations
    Authors: Mohadeseh Khoshandam, Hossein Soltaninejad, Amir Ali Hamidieh, Saman Hosseinkhani
    Journal: Preprint