Xiangya Hospital of Central South University | China
Xinyu Yang is a Hematology researcher and clinician–scientist whose work centers on the intersection of hematology, oncology, immunity, and coagulation disorders. His primary research interests include sepsis-associated disseminated intravascular coagulation (DIC), inflammation-driven thrombosis, cellular immunotherapy, and hematopoietic stem cell transplantation (HSCT). He has extensive experience in the clinical and translational management of hematologic malignancies, with a particular emphasis on leukemia, myelodysplastic syndromes, lymphoma, coagulation disorders, and HSCT. His laboratory research focuses on immune-based therapeutic strategies, including the application of CAR-T cell therapy for refractory leukemia, and he is proficient in key experimental techniques such as flow cytometry, cell culture, and ELISA. His academic work integrates mechanistic studies of coagulation activation, tissue factor regulation, and immune–coagulation crosstalk in sepsis. As a principal investigator and co-investigator on multiple competitive grants, his funded projects explore the molecular mechanisms of coagulation activation in sepsis, the pathophysiology of DIC, and epigenetic regulation of procoagulant pathways. Through combined clinical practice, laboratory research, and academic teaching, his work contributes to advancing precision immunotherapy, improving outcomes in hematologic diseases, and deepening understanding of inflammation–thrombosis interactions in critical illness.
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